Mus musculus Gene: Spink5 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-144109.6 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | Spink5 | ||||||||||||||||
Gene Name | serine peptidase inhibitor, Kazal type 5 | ||||||||||||||||
Synonyms | 2310065D10Rik; AV238912; LEKT1; LETK1; VAKT1 | ||||||||||||||||
Species | Mus musculus | ||||||||||||||||
Ensembl Gene | ENSMUSG00000055561 | ||||||||||||||||
Encoded Proteins |
serine peptidase inhibitor, Kazal type 5
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
InnateDB Annotation | |||||||||||||||||
Summary |
Spink5 binds to antimicrobial peptide dermcidin (DCD) and is involved in the trafficking of DCD in the epidermis. (Demonstrated in human)
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InnateDB Annotation from Orthologs | |||||||||||||||||
Summary |
[Homo sapiens] SPINK5 binds to antimicrobial peptide dermcidin (DCD) and is involved in the trafficking of DCD in the epidermis.
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Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133710:
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 18:43963235-44022501 | ||||||||||||||||
Strand | Forward strand | ||||||||||||||||
Band | B3 | ||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | |||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | |||||||||||||||||
UniGene | Mm.35369 | ||||||||||||||||
RefSeq | NM_001081180 XM_006526279 XM_006526280 | ||||||||||||||||
OMIM | |||||||||||||||||
CCDS | CCDS37805 | ||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
MGI ID | |||||||||||||||||
MGI Symbol | |||||||||||||||||
EMBL | |||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | |||||||||||||||||