Version 5.4
Homo sapiens Gene: SPINK5
Summary
InnateDB Gene IDBG-52343.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPINK5
Gene Name serine peptidase inhibitor, Kazal type 5
Synonyms LEKTI; LETKI; NETS; NS; VAKTI
Species Homo sapiens
Ensembl Gene ENSG00000133710
Encoded Proteins
IDBP-52345
serine peptidase inhibitor, Kazal type 5
IDBP-52347
serine peptidase inhibitor, Kazal type 5
IDBP-232940
serine peptidase inhibitor, Kazal type 5
IDBP-484026
serine peptidase inhibitor, Kazal type 5
IDBP-480560
serine peptidase inhibitor, Kazal type 5
IDBP-475980
serine peptidase inhibitor, Kazal type 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22588119
SPINK5 binds to antimicrobial peptide dermcidin (DCD) and is involved in the trafficking of DCD in the epidermis.
InnateDB Annotation from Orthologs
Summary
PMID 22588119
[Mus musculus] Spink5 binds to antimicrobial peptide dermcidin (DCD) and is involved in the trafficking of DCD in the epidermis. (Demonstrated in human)
Entrez Gene
Summary This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:148025683-148137289
Strand Forward strand
Band q32
Transcripts
ENST00000359874 ENSP00000352936
ENST00000256084 ENSP00000256084
ENST00000398454 ENSP00000381472
ENST00000521206 ENSP00000430264
ENST00000508733 ENSP00000421519
ENST00000476697 ENSP00000427943
ENST00000507988
ENST00000481286
ENST00000476608
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0009913 epidermal cell differentiation
GO:0010951 negative regulation of endopeptidase activity
GO:0016525 negative regulation of angiogenesis
GO:0030155 regulation of cell adhesion
GO:0030198 extracellular matrix organization
GO:0030855 epithelial cell differentiation
GO:0035315 hair cell differentiation
GO:0042640 anagen
GO:0045087 innate immune response (InnateDB)
GO:0045580 regulation of T cell differentiation
GO:0045861 negative regulation of proteolysis
GO:0050777 negative regulation of immune response
GO:1902572 negative regulation of serine-type peptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005938 cell cortex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0097209 epidermal lamellar body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055561
View Gene Order
ENSBTAG00000019140
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.331555
RefSeq NM_001127698 NM_001127699 NM_006846
HUGO
OMIM
CCDS CCDS43382 CCDS47300 CCDS47301
HPRD 05423
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca