Mus musculus Gene: Znrf3
Summary
InnateDB Gene IDBG-144715.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Znrf3
Gene Name zinc and ring finger 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041961
Encoded Proteins
zinc and ring finger 3
zinc and ring finger 3
zinc and ring finger 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183579:
Gene Information
Type Protein coding
Genomic Location Chromosome 11:5276324-5444847
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000109867 ENSMUSP00000105493
ENSMUST00000143746 ENSMUSP00000122475
ENSMUST00000172492 ENSMUSP00000134698
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0030178 negative regulation of Wnt signaling pathway
GO:0038018 Wnt receptor catabolic process
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0072089 stem cell proliferation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000051 negative regulation of non-canonical Wnt signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Disease pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
regulation of FZD by ubiquitination pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF dependent signaling in response to WNT pathway
Signal Transduction pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signal Transduction pathway
regulation of FZD by ubiquitination pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.216313 Mm.396089
RefSeq NM_001080924 NM_001290501 XM_006514744
OMIM
CCDS CCDS36102 CCDS70134
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas