InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Znrf3

Summary

InnateDB Protein

IDBP-261476.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Znrf3

Protein Name

zinc and ring finger 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105493

InnateDB Gene

IDBG-144715 (Znrf3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. {ECO:0000269PubMed:22575959, ECO:0000269PubMed:22895187}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0030178	negative regulation of Wnt signaling pathway
GO:0038018	Wnt receptor catabolic process
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0072089	stem cell proliferation
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000051	negative regulation of non-canonical Wnt signaling pathway