InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stab1

Summary

InnateDB Gene

IDBG-144883.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stab1

Gene Name

stabilin 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000042286

Encoded Proteins

IDBP-144885

stabilin 1

IDBP-535279

stabilin 1

IDBP-532678

stabilin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000010327:
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:31139013-31168641

Strand

Reverse strand

Band

Transcripts

ENSMUST00000036618	ENSMUSP00000046199
ENSMUST00000162169
ENSMUST00000159480
ENSMUST00000160024	ENSMUSP00000125239
ENSMUST00000161129
ENSMUST00000159208
ENSMUST00000160720
ENSMUST00000161631
ENSMUST00000159249	ENSMUSP00000125542
ENSMUST00000162763
ENSMUST00000161464
ENSMUST00000159757
ENSMUST00000159532

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005044	scavenger receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding
GO:0030169	low-density lipoprotein particle binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0007155	cell adhesion
GO:0007267	cell-cell signaling
GO:0016525	negative regulation of angiogenesis
GO:0042742	defense response to bacterium

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000010327

View Gene Order

ENSBTAG00000014782

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_164002

Scavenging by Class H Receptors pathway

REACT_160300

Binding and Uptake of Ligands by Scavenger Receptors pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.220821

RefSeq

NM_138672 XM_006518721

OMIM

CCDS

CCDS26906

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas