InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STAB1

Summary

InnateDB Gene

IDBG-39109.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAB1

Gene Name

stabilin 1

Synonyms

CLEVER-1; FEEL-1; FELE-1; FEX1; STAB-1

Species

Homo sapiens

Ensembl Gene

ENSG00000010327

Encoded Proteins

IDBP-39111

stabilin 1

IDBP-482935

stabilin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:52495338-52524495

Strand

Forward strand

Band

p21.1

Transcripts

ENST00000321725	ENSP00000312946
ENST00000481607
ENST00000479355
ENST00000484850
ENST00000461325
ENST00000481626
ENST00000462741
ENST00000462681
ENST00000469989	ENSP00000418426

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005044	scavenger receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0030169	low-density lipoprotein particle binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007267	cell-cell signaling
GO:0016525	negative regulation of angiogenesis
GO:0042742	defense response to bacterium
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0030666	endocytic vesicle membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000042286

View Gene Order

ENSBTAG00000014782

Not yet available

Pathways

NETPATH

REACTOME

REACT_164002

Scavenging by Class H Receptors pathway

REACT_160300

Binding and Uptake of Ligands by Scavenger Receptors pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

23166

UniGene

Hs.301989

RefSeq

NM_015136 XM_005264973 XM_005264974 XM_006713065

HUGO

HGNC:18628

OMIM

608560

CCDS

CCDS33768

HPRD

09778

IMGT

EMBL

GenPept

RNA Seq Atlas

23166