Version 5.4
Mus musculus Gene: Grin1
Summary
InnateDB Gene IDBG-144904.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grin1
Gene Name glutamate receptor, ionotropic, NMDA1 (zeta 1)
Synonyms GluN1; GluRdelta1; GluRzeta1; M100174; NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174
Species Mus musculus
Ensembl Gene ENSMUSG00000026959
Encoded Proteins
IDBP-144906
glutamate receptor, ionotropic, NMDA1 (zeta 1)
IDBP-252009
glutamate receptor, ionotropic, NMDA1 (zeta 1)
IDBP-252011
glutamate receptor, ionotropic, NMDA1 (zeta 1)
IDBP-252013
glutamate receptor, ionotropic, NMDA1 (zeta 1)
IDBP-252015
glutamate receptor, ionotropic, NMDA1 (zeta 1)
IDBP-252017
glutamate receptor, ionotropic, NMDA1 (zeta 1)
IDBP-252019
glutamate receptor, ionotropic, NMDA1 (zeta 1)
IDBP-252021
glutamate receptor, ionotropic, NMDA1 (zeta 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176884:
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:25291181-25319187
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000028335 ENSMUSP00000028335
ENSMUST00000114318 ENSMUSP00000109957
ENSMUST00000114317 ENSMUSP00000109956
ENSMUST00000114314 ENSMUSP00000109953
ENSMUST00000114312 ENSMUSP00000109951
ENSMUST00000114310 ENSMUSP00000109949
ENSMUST00000114308 ENSMUSP00000109947
ENSMUST00000114307 ENSMUSP00000109946
ENSMUST00000127171
ENSMUST00000135426
ENSMUST00000153465
ENSMUST00000153551
ENSMUST00000155627
ENSMUST00000144402
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 96 [view]
Protein-Protein 96 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity
GO:0005102 receptor binding
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0016594 glycine binding
GO:0016595 glutamate binding
GO:0019899 enzyme binding
GO:0022843 voltage-gated cation channel activity
GO:0035254 glutamate receptor binding
GO:0042165 neurotransmitter binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001661 conditioned taste aversion
GO:0001964 startle response
GO:0001967 suckling behavior
GO:0001975 response to amphetamine
GO:0006810 transport
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0007268 synaptic transmission
GO:0007585 respiratory gaseous exchange
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007616 long-term memory
GO:0008306 associative learning
GO:0008344 adult locomotory behavior
GO:0008355 olfactory learning
GO:0008542 visual learning
GO:0010646 regulation of cell communication
GO:0010942 positive regulation of cell death
GO:0014070 response to organic cyclic compound
GO:0014075 response to amine
GO:0018964 propylene metabolic process
GO:0019233 sensory perception of pain
GO:0021586 pons maturation
GO:0021987 cerebral cortex development
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035176 social behavior
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0042391 regulation of membrane potential
GO:0043065 positive regulation of apoptotic process
GO:0043278 response to morphine
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043576 regulation of respiratory gaseous exchange
GO:0045471 response to ethanol
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048511 rhythmic process
GO:0048814 regulation of dendrite morphogenesis
GO:0050770 regulation of axonogenesis
GO:0050905 neuromuscular process
GO:0051262 protein tetramerization
GO:0051592 response to calcium ion
GO:0051963 regulation of synapse assembly
GO:0055074 calcium ion homeostasis
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060134 prepulse inhibition
GO:0060179 male mating behavior
GO:0060992 response to fungicide
GO:0070588 calcium ion transmembrane transport
GO:0071287 cellular response to manganese ion
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005887 integral component of plasma membrane
GO:0008021 synaptic vesicle
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 cell junction
GO:0030425 dendrite
GO:0030426 growth cone
GO:0032590 dendrite membrane
GO:0043083 synaptic cleft
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000176884
View Gene Order
ENSBTAG00000047202
Not yet available
Pathways
NETPATH
REACTOME
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_198244
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_198246
CREB phosphorylation through the activation of Ras pathway
REACT_198248
CREB phosphorylation through the activation of CaMKII pathway
REACT_218233
Post NMDA receptor activation events pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_261444
Axon guidance pathway
REACT_259290
Neuronal System pathway
REACT_188576
Developmental Biology pathway
REACT_258217
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_214376
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu05010
Alzheimer's disease pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
mmu04720
Long-term potentiation pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu05016
Huntington's disease pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20546
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_20642
CREB phosphorylation through the activation of CaMKII pathway
REACT_20594
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_111045
Developmental Biology pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_13685
Neuronal System pathway
REACT_18266
Axon guidance pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa04020
Calcium signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa05016
Huntington's disease pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.278672 Mm.397645
RefSeq NM_001177656 NM_001177657 NM_008169 XM_006497722 XM_006497723 XM_006497724 XM_006497725 XM_006497726
OMIM
CCDS CCDS15764 CCDS50528 CCDS50529
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca