Version 5.4
Homo sapiens Gene: GNB1L
Summary
InnateDB Gene IDBG-1450.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNB1L
Gene Name guanine nucleotide binding protein (G protein), beta polypeptide 1-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185838
Encoded Proteins
IDBP-1452
guanine nucleotide binding protein (G protein), beta polypeptide 1-like
IDBP-292515
guanine nucleotide binding protein (G protein), beta polypeptide 1-like
IDBP-292516
guanine nucleotide binding protein (G protein), beta polypeptide 1-like
IDBP-362126
guanine nucleotide binding protein (G protein), beta polypeptide 1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:19783224-19854939
Strand Reverse strand
Band q11.21
Transcripts
ENST00000329517 ENSP00000331313
ENST00000405009 ENSP00000384626
ENST00000403325 ENSP00000385154
ENST00000453108 ENSP00000389412
ENST00000460402
ENST00000481086
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0035176 social behavior
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0009898 cytoplasmic side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000884
View Gene Order
ENSBTAG00000021052
Not yet available
Cross-References
SwissProt Q9BYB4
TrEMBL
UniProt Splice Variant
Entrez Gene 54584
UniGene
RefSeq NM_053004
HUGO HGNC:4397
OMIM 610778
CCDS CCDS13768
HPRD 13591
IMGT
EMBL AB049212 AB051432 AF238328 AF301895 AY007378 BC012060 CR456496
GenPept AAG12162 AAG36826 AAG53933 AAH12060 BAB33315 BAB68408 CAG30382
RNA Seq Atlas 54584

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca