Version 5.4
Mus musculus Gene: Foxe1
Summary
InnateDB Gene IDBG-145124.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Foxe1
Gene Name forkhead box E1
Synonyms Titf2
Species Mus musculus
Ensembl Gene ENSMUSG00000070990
Encoded Proteins
IDBP-145126
forkhead box E1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178919:
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:46343609-46346412
Strand Forward strand
Band B1
Transcripts
ENSMUST00000095097 ENSMUSP00000092715
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002089 lens morphogenesis in camera-type eye
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006590 thyroid hormone generation
GO:0007389 pattern specification process
GO:0016477 cell migration
GO:0030878 thyroid gland development
GO:0031069 hair follicle morphogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048538 thymus development
GO:0048562 embryonic organ morphogenesis
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0060022 hard palate development
GO:0060023 soft palate development
GO:0060465 pharynx development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178919
View Gene Order
ENSBTAG00000014760
Not yet available
Cross-References
SwissProt Q8R2I0
TrEMBL
UniProt Splice Variant
Entrez Gene 110805
UniGene Mm.354634 Mm.489295
RefSeq NM_183298
OMIM
CCDS CCDS18147
HPRD
IMGT
MGI ID MGI:1353500
MGI Symbol Foxe1
EMBL AJ457047 AL806523
GenPept CAD29716 CAM23955
RNA Seq Atlas 110805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca