InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxe1

Summary

InnateDB Protein

IDBP-145126.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxe1

Protein Name

forkhead box E1

Synonyms

Titf2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092715

InnateDB Gene

IDBG-145124 (Foxe1)

Protein Structure

UniProt Annotation

Function

Probable transcription factor. Could be involved in thyroid gland organogenesis.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089}.

Disease Associations

Tissue Specificity

Expressed in Rathke pouch, in thyroid, and in the epithelium of the pharyngeal wall and arches, whereas it is absent in the epithelium of the pharyngeal pouches. {ECO:0000269PubMed:12203737}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002089	lens morphogenesis in camera-type eye
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006590	thyroid hormone generation
GO:0007389	pattern specification process
GO:0016477	cell migration
GO:0030878	thyroid gland development
GO:0031069	hair follicle morphogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048538	thymus development
GO:0048562	embryonic organ morphogenesis
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0060022	hard palate development
GO:0060023	soft palate development
GO:0060465	pharynx development