Version 5.4
Mus musculus Gene: Hadha
Summary
InnateDB Gene IDBG-145161.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hadha
Gene Name hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
Synonyms C77020; Mtpa
Species Mus musculus
Ensembl Gene ENSMUSG00000025745
Encoded Proteins
IDBP-539024
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084754:
This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:30118301-30155162
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000026843
ENSMUST00000156859 ENSMUSP00000120976
ENSMUST00000132486
ENSMUST00000126081
ENSMUST00000130358
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0003824 catalytic activity
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0004300 enoyl-CoA hydratase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016508 long-chain-enoyl-CoA hydratase activity
GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0032403 protein complex binding
GO:0051287 NAD binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0032868 response to insulin
GO:0042493 response to drug
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex
GO:0042645 mitochondrial nucleoid
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000084754
View Gene Order
ENSBTAG00000015038
Not yet available
Pathways
NETPATH
REACTOME
REACT_199034
Acyl chain remodeling of CL pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_233858
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_237597
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_188937
Metabolism pathway
REACT_236353
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_261839
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_257646
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_256910
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_239107
Beta oxidation of myristoyl-CoA to lauroyl-CoA pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
REACT_251878
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
KEGG
mmu00410
beta-Alanine metabolism pathway
mmu01040
Biosynthesis of unsaturated fatty acids pathway
mmu00280
Valine, leucine and isoleucine degradation pathway
mmu00062
Fatty acid elongation pathway
mmu00310
Lysine degradation pathway
mmu00380
Tryptophan metabolism pathway
mmu00640
Propanoate metabolism pathway
mmu00650
Butanoate metabolism pathway
mmu00071
Fatty acid degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121006
Acyl chain remodeling of CL pathway
REACT_1887
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
REACT_2108
Beta oxidation of myristoyl-CoA to lauroyl-CoA pathway
REACT_2025
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
REACT_735
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
REACT_1697
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
REACT_1708
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1473
Mitochondrial Fatty Acid Beta-Oxidation pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_1541
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
REACT_111217
Metabolism pathway
KEGG
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00650
Butanoate metabolism pathway
hsa00640
Propanoate metabolism pathway
hsa01040
Biosynthesis of unsaturated fatty acids pathway
hsa00380
Tryptophan metabolism pathway
hsa00071
Fatty acid degradation pathway
hsa00062
Fatty acid elongation pathway
hsa00310
Lysine degradation pathway
hsa00410
beta-Alanine metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Propanoate metabolism pathway
INOH website
Butanoate metabolism pathway
INOH website
Valine Leucine Isoleucine degradation pathway
INOH website
Lysine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.200497
RefSeq NM_178878
OMIM
CCDS CCDS19155
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca