Version 5.4
| Bos taurus Gene: HADHA | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-637102.3 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | HADHA | ||||||||||||||||||
| Gene Name | trifunctional enzyme subunit alpha, mitochondrial precursor | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||
| Ensembl Gene | ENSBTAG00000015038 | ||||||||||||||||||
| Encoded Proteins |
trifunctional enzyme subunit alpha, mitochondrial
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084754:
This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 11:73246485-73288803 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | |||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Acyl chain remodeling of CL pathway
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
Beta oxidation of myristoyl-CoA to lauroyl-CoA pathway
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism of lipids and lipoproteins pathway
Mitochondrial Fatty Acid Beta-Oxidation pathway
Glycerophospholipid biosynthesis pathway
Phospholipid metabolism pathway
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
Metabolism pathway
Acyl chain remodeling of CL pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Mitochondrial Fatty Acid Beta-Oxidation pathway
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
Metabolism pathway
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
Metabolism of lipids and lipoproteins pathway
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
Beta oxidation of myristoyl-CoA to lauroyl-CoA pathway
Glycerophospholipid biosynthesis pathway
Phospholipid metabolism pathway
Beta oxidation of palmitoyl-CoA to myristoyl-CoA pathway
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| KEGG |
Valine, leucine and isoleucine degradation pathway
Butanoate metabolism pathway
Propanoate metabolism pathway
Biosynthesis of unsaturated fatty acids pathway
Tryptophan metabolism pathway
Fatty acid degradation pathway
Fatty acid elongation pathway
Lysine degradation pathway
beta-Alanine metabolism pathway
beta-Alanine metabolism pathway
Biosynthesis of unsaturated fatty acids pathway
Valine, leucine and isoleucine degradation pathway
Fatty acid elongation pathway
Lysine degradation pathway
Tryptophan metabolism pathway
Propanoate metabolism pathway
Butanoate metabolism pathway
Fatty acid degradation pathway
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| INOH |
Tryptophan degradation pathway
Propanoate metabolism pathway
Butanoate metabolism pathway
Valine Leucine Isoleucine degradation pathway
Lysine degradation pathway
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| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | Q3SZ00 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 281810 | ||||||||||||||||||
| UniGene | Bt.48598 | ||||||||||||||||||
| RefSeq | NM_174335 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | |||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | BC103307 DAAA02031607 DAAA02031608 | ||||||||||||||||||
| GenPept | AAI03308 | ||||||||||||||||||
| RNA Seq Atlas | 281810 | ||||||||||||||||||