InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ticam2

Summary

InnateDB Gene

IDBG-145267.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ticam2

Gene Name

toll-like receptor adaptor molecule 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000056130

Encoded Proteins

IDBP-145269

toll-like receptor adaptor molecule 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21494017

Ticam2 deficiency results in the impairment of LPS-stimulated TNF-alpha protein translation.

PMID 25505250

Adaptor proteins Ticam1 and Ticam2 have a novel function in Tlr2-mediated signal transduction.

PMID 26065469

Ticam2 mediates antibacterial defence during Gram-negative pneumonia by inducing Ifng at the primary site of infection.

PMID 25808990

Intracellular Sef/IL-17R (SEFIR) domain of Il17rd targets TIR adaptor proteins Myd88, Tirap, Ticam1, Ticam2 and Traf6 to inhibit TLR downstream signalling.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:46559155-46574533

Strand

Reverse strand

Band

Transcripts

ENSMUST00000070084	ENSMUSP00000066239
ENSMUST00000149929

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005149	interleukin-1 receptor binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001817	regulation of cytokine production
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0032729	positive regulation of interferon-gamma production
GO:0032755	positive regulation of interleukin-6 production
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0035669	TRAM-dependent toll-like receptor 4 signaling pathway
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0070671	response to interleukin-12
GO:0071222	cellular response to lipopolysaccharide
GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production
GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production
GO:2000494	positive regulation of interleukin-18-mediated signaling pathway

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0045323	interleukin-1 receptor complex