InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ticam2

Summary

InnateDB Protein

IDBP-145269.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ticam2

Protein Name

toll-like receptor adaptor molecule 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066239

InnateDB Gene

IDBG-145267 (Ticam2)

Protein Structure

UniProt Annotation

Function

Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. {ECO:0000269PubMed:14556004, ECO:0000269PubMed:18297073, ECO:0000269PubMed:22685567}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000269PubMed:18297073}. Early endosome {ECO:0000269PubMed:18297073}. Late endosome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Localized to the plasma membrane as a result of myristoylation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005149	interleukin-1 receptor binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001817	regulation of cytokine production
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0032729	positive regulation of interferon-gamma production
GO:0032755	positive regulation of interleukin-6 production
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0035669	TRAM-dependent toll-like receptor 4 signaling pathway
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0070671	response to interleukin-12
GO:0071222	cellular response to lipopolysaccharide
GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production
GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production
GO:2000494	positive regulation of interleukin-18-mediated signaling pathway

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0045323	interleukin-1 receptor complex