InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp6v0c

Summary

InnateDB Gene

IDBG-145384.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v0c

Gene Name

ATPase, H+ transporting, lysosomal V0 subunit C

Synonyms

Atp6c; Atp6c2; Atp6l; Atpl; Atpl-rs1; PL16; VATL; Vma3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024121

Encoded Proteins

IDBP-145386

ATPase, H+ transporting, lysosomal V0 subunit C

IDBP-249727

ATPase, H+ transporting, lysosomal V0 subunit C

IDBP-533278

ATPase, H+ transporting, lysosomal V0 subunit C

IDBP-532509

ATPase, H+ transporting, lysosomal V0 subunit C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185883:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:24163866-24169702

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000024932	ENSMUSP00000024932
ENSMUST00000098862	ENSMUSP00000111059
ENSMUST00000151061
ENSMUST00000148541	ENSMUSP00000121464
ENSMUST00000156061
ENSMUST00000150647	ENSMUSP00000122843

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0007035	vacuolar acidification
GO:0007042	lysosomal lumen acidification
GO:0015991	ATP hydrolysis coupled proton transport
GO:0030177	positive regulation of Wnt signaling pathway

Cellular Component

GO:0005765	lysosomal membrane
GO:0016021	integral component of membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0070062	extracellular vesicular exosome