InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATP6V0C

Summary

InnateDB Gene

IDBG-635530.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0C

Gene Name

V-type proton ATPase 16 kDa proteolipid subunit

Synonyms

PLP

Species

Bos taurus

Ensembl Gene

ENSBTAG00000026428

Encoded Proteins

IDBP-687369

V-type proton ATPase 16 kDa proteolipid subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185883:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:2014229-2019603

Strand

Forward strand

Band

Transcripts

ENSBTAT00000037556

ENSBTAP00000037385

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016787	hydrolase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0008152	metabolic process
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0030177	positive regulation of Wnt signaling pathway

Cellular Component

GO:0005765	lysosomal membrane
GO:0005773	vacuole
GO:0005774	vacuolar membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0070062	extracellular vesicular exosome