InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aebp1

Summary

InnateDB Gene

IDBG-145390.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aebp1

Gene Name

AE binding protein 1

Synonyms

ACLP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020473

Encoded Proteins

IDBP-145394

AE binding protein 1

IDBP-261548

AE binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106624:
The adipocyte enhancer binding protein 1 is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascular smooth muscle cells. [provided by RefSeq, Jul 2008]
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:5861947-5872088

Strand

Forward strand

Band

Transcripts

ENSMUST00000102923	ENSMUSP00000099987
ENSMUST00000109829	ENSMUSP00000105454
ENSMUST00000138103

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0004180	carboxypeptidase activity
GO:0004181	metallocarboxypeptidase activity
GO:0005516	calmodulin binding
GO:0008270	zinc ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006508	proteolysis
GO:0007155	cell adhesion

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000106624

View Gene Order

ENSBTAG00000012237

Not yet available

Cross-References

SwissProt

Q640N1

TrEMBL

UniProt Splice Variant

Entrez Gene

11568

UniGene

Mm.4665 Mm.481533

RefSeq

NM_001291857 NM_009636 XM_006514460

OMIM

CCDS

CCDS24406

HPRD

IMGT

MGI ID

MGI:1197012

MGI Symbol

Aebp1

EMBL

AF053943 AK159330 AK159342 AK159377 AK159409 AK159774 AK159957 AL627069 BC082577 X80478

GenPept

AAC25584 AAH82577 BAE34995 BAE35004 BAE35033 BAE35060 BAE35359 BAE35513 CAA56648 CAI25440 CAI25441

RNA Seq Atlas

11568