InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aebp1

Summary

InnateDB Protein

IDBP-261548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aebp1

Protein Name

AE binding protein 1

Synonyms

ACLP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105454

InnateDB Gene

IDBG-145390 (Aebp1)

Protein Structure

UniProt Annotation

Function

Isoform 2 may positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. Isoform 2 may also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. {ECO:0000269PubMed:10406805, ECO:0000269PubMed:11152475, ECO:0000269PubMed:11438679, ECO:0000269PubMed:14729459, ECO:0000269PubMed:16307171, ECO:0000269PubMed:16461908, ECO:0000269PubMed:16538615, ECO:0000269PubMed:17202411, ECO:0000269PubMed:7477299}.

Subcellular Localization

Isoform 1: Secreted.Isoform 2: Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are expressed in adipose tissue, brain, heart, kidney, liver, lung, skeletal muscle, small intestine, spleen and testis. Isoform 2 is expressed in macrophages. Expressed in aorta, preadipocytes, adipocyte tissue, brain, heart, liver, lung, skeletal muscle, skin and spleen (at protein level). {ECO:0000269PubMed:11438679, ECO:0000269PubMed:11738825, ECO:0000269PubMed:9624159}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0004180	carboxypeptidase activity
GO:0004181	metallocarboxypeptidase activity
GO:0005516	calmodulin binding
GO:0008270	zinc ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006508	proteolysis
GO:0007155	cell adhesion

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1197012

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000834 Peptidase M14, carboxypeptidase A
IPR008969 Carboxypeptidase-like, regulatory domain
IPR008979 Galactose-binding domain-like

PFAM

PF00754
PF00246

PRINTS

PR00765

PIRSF

SMART

SM00231
SM00631

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt