Version 5.4
Homo sapiens Gene: GRM7
Summary
InnateDB Gene IDBG-14568.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRM7
Gene Name glutamate receptor, metabotropic 7
Synonyms GLUR7; GPRC1G; MGLU7; MGLUR7; PPP1R87
Species Homo sapiens
Ensembl Gene ENSG00000196277
Encoded Proteins
IDBP-14570
glutamate receptor, metabotropic 7
IDBP-14576
glutamate receptor, metabotropic 7
IDBP-14580
glutamate receptor, metabotropic 7
IDBP-292475
glutamate receptor, metabotropic 7
IDBP-361047
glutamate receptor, metabotropic 7
IDBP-361057
glutamate receptor, metabotropic 7
IDBP-361074
glutamate receptor, metabotropic 7
IDBP-361076
glutamate receptor, metabotropic 7
IDBP-361077
glutamate receptor, metabotropic 7
IDBP-478425
glutamate receptor, metabotropic 7
IDBP-483455
glutamate receptor, metabotropic 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:6770001-7741533
Strand Forward strand
Band p26.1
Transcripts
ENST00000357716 ENSP00000350348
ENST00000389336 ENSP00000373987
ENST00000389335 ENSP00000373986
ENST00000402647 ENSP00000384585
ENST00000443259 ENSP00000404161
ENST00000448328 ENSP00000393799
ENST00000435689 ENSP00000405194
ENST00000440923 ENSP00000412329
ENST00000445087 ENSP00000395035
ENST00000458641
ENST00000467425 ENSP00000419835
ENST00000486284 ENSP00000417536
ENST00000461677
ENST00000463676
ENST00000471242
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001642 group III metabotropic glutamate receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005245 voltage-gated calcium channel activity
GO:0005246 calcium channel regulator activity
GO:0005509 calcium ion binding
GO:0008066 glutamate receptor activity
GO:0010855 adenylate cyclase inhibitor activity
GO:0016595 glutamate binding
GO:0030165 PDZ domain binding
GO:0070905 serine binding
Biological Process
GO:0001661 conditioned taste aversion
GO:0001662 behavioral fear response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007605 sensory perception of sound
GO:0007608 sensory perception of smell
GO:0007613 memory
GO:0007614 short-term memory
GO:0008306 associative learning
GO:0014050 negative regulation of glutamate secretion
GO:0019226 transmission of nerve impulse
GO:0030534 adult behavior
GO:0030818 negative regulation of cAMP biosynthetic process
GO:0031279 regulation of cyclase activity
GO:0033555 multicellular organismal response to stress
GO:0050877 neurological system process
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005938 cell cortex
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0032279 asymmetric synapse
GO:0042734 presynaptic membrane
GO:0043198 dendritic shaft
GO:0043235 receptor complex
GO:0045211 postsynaptic membrane
GO:0048786 presynaptic active zone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056755
View Gene Order
ENSBTAG00000013047
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_18319
Class C/3 (Metabotropic glutamate/pheromone receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.606393 Hs.660131
RefSeq NM_000844 NM_181874 XM_005265095
HUGO
OMIM
CCDS CCDS43042
HPRD 04979
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca