InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grm7

Summary

InnateDB Gene

IDBG-174797.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm7

Gene Name

glutamate receptor, metabotropic 7

Synonyms

6330570A01Rik; BB176677; C030018L03; E130018M02Rik; Gpr1g; Gprc1g; mGluR7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000056755

Encoded Proteins

IDBP-174799

glutamate receptor, metabotropic 7

IDBP-624489

glutamate receptor, metabotropic 7

IDBP-624496

glutamate receptor, metabotropic 7

IDBP-624497

glutamate receptor, metabotropic 7

IDBP-624498

glutamate receptor, metabotropic 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196277:
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:110645581-111567230

Strand

Forward strand

Band

Transcripts

ENSMUST00000071076	ENSMUSP00000064404
ENSMUST00000174018	ENSMUSP00000134635
ENSMUST00000172951	ENSMUSP00000133957
ENSMUST00000173001	ENSMUSP00000134233
ENSMUST00000174310	ENSMUSP00000133897

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001642	group III metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005245	voltage-gated calcium channel activity
GO:0005246	calcium channel regulator activity
GO:0005509	calcium ion binding
GO:0008066	glutamate receptor activity
GO:0010855	adenylate cyclase inhibitor activity
GO:0016595	glutamate binding
GO:0030165	PDZ domain binding
GO:0070905	serine binding

Biological Process

GO:0001661	conditioned taste aversion
GO:0001662	behavioral fear response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007605	sensory perception of sound
GO:0007608	sensory perception of smell
GO:0007613	memory
GO:0007614	short-term memory
GO:0008306	associative learning
GO:0019226	transmission of nerve impulse
GO:0030534	adult behavior
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0031279	regulation of cyclase activity
GO:0033555	multicellular organismal response to stress
GO:0050877	neurological system process
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0070588	calcium ion transmembrane transport
GO:1901214	regulation of neuron death

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0005938	cell cortex
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0042734	presynaptic membrane
GO:0043235	receptor complex
GO:0048787	presynaptic active zone membrane