InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gabbr2

Summary

InnateDB Gene

IDBG-145697.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gabbr2

Gene Name

gamma-aminobutyric acid (GABA) B receptor, 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039809

Encoded Proteins

IDBP-266012

gamma-aminobutyric acid (GABA) B receptor, 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136928:
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:46662318-46991873

Strand

Reverse strand

Band

Transcripts

ENSMUST00000107749	ENSMUSP00000103378
ENSMUST00000129328

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004965	G-protein coupled GABA receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007214	gamma-aminobutyric acid signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0038039	G-protein coupled receptor heterodimeric complex
GO:0043005	neuron projection
GO:0045211	postsynaptic membrane