InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pygl

Summary

InnateDB Gene

IDBG-145721.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pygl

Gene Name

liver glycogen phosphorylase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021069

Encoded Proteins

IDBP-145723

liver glycogen phosphorylase

IDBP-540183

liver glycogen phosphorylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100504:
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:70190811-70231488

Strand

Reverse strand

Band

Transcripts

ENSMUST00000071250	ENSMUSP00000071231
ENSMUST00000161083	ENSMUSP00000125585
ENSMUST00000162613
ENSMUST00000161840
ENSMUST00000166609

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002060	purine nucleobase binding
GO:0004645	phosphorylase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008144	drug binding
GO:0008184	glycogen phosphorylase activity
GO:0016208	AMP binding
GO:0019842	vitamin binding
GO:0030170	pyridoxal phosphate binding
GO:0030246	carbohydrate binding
GO:0032052	bile acid binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005977	glycogen metabolic process
GO:0005980	glycogen catabolic process
GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process
GO:0042593	glucose homeostasis
GO:0070266	necroptotic process