InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PYGL

Summary

InnateDB Gene

IDBG-646461.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PYGL

Gene Name

Glycogen phosphorylase, liver form

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011494

Encoded Proteins

IDBP-699271

Glycogen phosphorylase, liver form

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100504:
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:43800152-43840994

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015277

ENSBTAP00000015277

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0002060	purine nucleobase binding
GO:0003824	catalytic activity
GO:0004645	phosphorylase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008144	drug binding
GO:0008184	glycogen phosphorylase activity
GO:0016208	AMP binding
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0019842	vitamin binding
GO:0030170	pyridoxal phosphate binding
GO:0032052	bile acid binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005977	glycogen metabolic process
GO:0008152	metabolic process
GO:0042593	glucose homeostasis
GO:0070266	necroptotic process