InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bap1

Summary

InnateDB Gene

IDBG-145802.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bap1

Gene Name

Brca1 associated protein 1

Synonyms

2300006C11Rik; AA989761; AW553466; mKIAA0272; uch-x4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021901

Encoded Proteins

IDBP-145804

Brca1 associated protein 1

IDBP-787855

Brca1 associated protein 1

IDBP-787856

Brca1 associated protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163930:
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene. [provided by RefSeq, Jul 2008]
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:31251450-31259944

Strand

Forward strand

Band

Transcripts

ENSMUST00000022458	ENSMUSP00000022458
ENSMUST00000188714
ENSMUST00000189834
ENSMUST00000190788
ENSMUST00000188453	ENSMUSP00000139824
ENSMUST00000187156	ENSMUSP00000139903
ENSMUST00000185987
ENSMUST00000185700

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008285	negative regulation of cell proliferation
GO:0016579	protein deubiquitination
GO:0035520	monoubiquitinated protein deubiquitination
GO:0035522	monoubiquitinated histone H2A deubiquitination
GO:0051726	regulation of cell cycle
GO:0071108	protein K48-linked deubiquitination

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0035517	PR-DUB complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000163930

View Gene Order

ENSBTAG00000045817

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_027088

OMIM

CCDS

CCDS26910

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas