InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.20209

Summary

InnateDB Gene

IDBG-645609.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.20209

Gene Name

ubiquitin carboxyl-terminal hydrolase BAP1

Synonyms

BAIAP3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000045817

Encoded Proteins

IDBP-698333

BRCA1 associated protein-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163930:
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene. [provided by RefSeq, Jul 2008]
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:49032830-49039996

Strand

Forward strand

Band

Transcripts

ENSBTAT00000064109

ENSBTAP00000054730

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016579	protein deubiquitination
GO:0035520	monoubiquitinated protein deubiquitination
GO:0035522	monoubiquitinated histone H2A deubiquitination
GO:0051726	regulation of cell cycle
GO:0071108	protein K48-linked deubiquitination

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0035517	PR-DUB complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000163930

View Gene Order

ENSMUSG00000021901

View Gene Order

Cross-References

SwissProt

TrEMBL

G3MYU1

UniProt Splice Variant

Entrez Gene

100124510

UniGene

Bt.20209

RefSeq

NM_001102549

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02054377 DAAA02054378

GenPept

RNA Seq Atlas

100124510

Transcript Frequencies

Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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