Version 5.4
Mus musculus Gene: Camk2b
Summary
InnateDB Gene IDBG-145820.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Camk2b
Gene Name calcium/calmodulin-dependent protein kinase II, beta
Synonyms Camk2d
Species Mus musculus
Ensembl Gene ENSMUSG00000057897
Encoded Proteins
IDBP-145822
calcium/calmodulin-dependent protein kinase II, beta
IDBP-145824
calcium/calmodulin-dependent protein kinase II, beta
IDBP-145826
calcium/calmodulin-dependent protein kinase II, beta
IDBP-145828
calcium/calmodulin-dependent protein kinase II, beta
IDBP-145830
calcium/calmodulin-dependent protein kinase II, beta
IDBP-145832
calcium/calmodulin-dependent protein kinase II, beta
IDBP-145834
calcium/calmodulin-dependent protein kinase II, beta
IDBP-261581
calcium/calmodulin-dependent protein kinase II, beta
IDBP-261583
calcium/calmodulin-dependent protein kinase II, beta
IDBP-261585
calcium/calmodulin-dependent protein kinase II, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000058404:
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:5969644-6066362
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000019133 ENSMUSP00000019133
ENSMUST00000090443 ENSMUSP00000087925
ENSMUST00000093355 ENSMUSP00000091046
ENSMUST00000002817 ENSMUSP00000002817
ENSMUST00000101586 ENSMUSP00000099120
ENSMUST00000101585 ENSMUSP00000099119
ENSMUST00000066431 ENSMUSP00000065101
ENSMUST00000109815 ENSMUSP00000105440
ENSMUST00000109813 ENSMUSP00000105438
ENSMUST00000109812 ENSMUSP00000105437
ENSMUST00000155755
ENSMUST00000154197
ENSMUST00000130427
ENSMUST00000123391
ENSMUST00000129098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0002030 inhibitory G-protein coupled receptor phosphorylation
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0010976 positive regulation of neuron projection development
GO:0018105 peptidyl-serine phosphorylation
GO:0032222 regulation of synaptic transmission, cholinergic
GO:0046686 response to cadmium ion
GO:0046777 protein autophosphorylation
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050885 neuromuscular process controlling balance
GO:0060466 activation of meiosis involved in egg activation
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0090129 positive regulation of synapse maturation
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005954 calcium- and calmodulin-dependent protein kinase complex
GO:0033017 sarcoplasmic reticulum membrane
GO:0051233 spindle midzone
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000058404
View Gene Order
Pathways
NETPATH
REACTOME
REACT_188957
Cellular responses to stress pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_198244
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_198246
CREB phosphorylation through the activation of Ras pathway
REACT_198248
CREB phosphorylation through the activation of CaMKII pathway
REACT_230745
Immune System pathway
REACT_218233
Post NMDA receptor activation events pathway
REACT_213550
HSF1-dependent transactivation pathway
REACT_224790
Cellular response to heat stress pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_259290
Neuronal System pathway
REACT_258217
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_214376
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
KEGG
mmu04740
Olfactory transduction pathway
mmu04012
ErbB signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu04916
Melanogenesis pathway
mmu04310
Wnt signaling pathway pathway
mmu04912
GnRH signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu05214
Glioma pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04114
Oocyte meiosis pathway
mmu04971
Gastric acid secretion pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_25078
Interferon gamma signaling pathway
REACT_20546
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_20568
CREB phosphorylation through the activation of Ras pathway
REACT_20642
CREB phosphorylation through the activation of CaMKII pathway
REACT_20594
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_120956
Cellular responses to stress pathway
REACT_13685
Neuronal System pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_20593
Post NMDA receptor activation events pathway
REACT_6900
Immune System pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_200775
HSF1-dependent transactivation pathway
REACT_200819
Cellular response to heat stress pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04310
Wnt signaling pathway pathway
hsa04740
Olfactory transduction pathway
hsa04012
ErbB signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa05214
Glioma pathway
hsa04020
Calcium signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04114
Oocyte meiosis pathway
hsa04971
Gastric acid secretion pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
ras_pathway
Regulation of Ras family activation
p38_mkk3_6pathway
p38 MAPK signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.439733 Mm.467664 Mm.486053
RefSeq NM_001174053 NM_001174054 NM_007595 XM_006514472
OMIM
CCDS CCDS24411 CCDS48748 CCDS48749
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca