InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Camk2b

Summary

InnateDB Protein

IDBP-261581.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Camk2b

Protein Name

calcium/calmodulin-dependent protein kinase II, beta

Synonyms

Camk2d;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105440

InnateDB Gene

IDBG-145820 (Camk2b)

Protein Structure

UniProt Annotation

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. {ECO:0000269PubMed:21752990}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Sarcoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0002030	inhibitory G-protein coupled receptor phosphorylation
GO:0006468	protein phosphorylation
GO:0006816	calcium ion transport
GO:0010976	positive regulation of neuron projection development
GO:0018105	peptidyl-serine phosphorylation
GO:0032222	regulation of synaptic transmission, cholinergic
GO:0046686	response to cadmium ion
GO:0046777	protein autophosphorylation
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0050885	neuromuscular process controlling balance
GO:0060466	activation of meiosis involved in egg activation
GO:0061003	positive regulation of dendritic spine morphogenesis
GO:0090129	positive regulation of synapse maturation
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005954	calcium- and calmodulin-dependent protein kinase complex
GO:0033017	sarcoplasmic reticulum membrane
GO:0051233	spindle midzone

Protein Structure and Domains

PDB ID

MGI:88257

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF08332

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt