Mus musculus Gene: Chrnb3 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||
InnateDB Gene | IDBG-146022.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Chrnb3 | ||||||||||||
Gene Name | cholinergic receptor, nicotinic, beta polypeptide 3 | ||||||||||||
Synonyms | 5730417K16Rik; Acrb3 | ||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Gene | ENSMUSG00000031492 | ||||||||||||
Encoded Proteins |
cholinergic receptor, nicotinic, beta polypeptide 3
cholinergic receptor, nicotinic, beta polypeptide 3
|
||||||||||||
Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147432:
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010] |
||||||||||||
Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 8:27368711-27399729 | ||||||||||||
Strand | Forward strand | ||||||||||||
Band | A2 | ||||||||||||
Transcripts |
|
||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||||||||||||
Gene Ontology | |||||||||||||
Molecular Function |
|
||||||||||||
Biological Process |
|
||||||||||||
Cellular Component |
|
||||||||||||
Orthologs | |||||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||
Pathways | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Presynaptic nicotinic acetylcholine receptors pathway
Neuronal System pathway
Activation of Nicotinic Acetylcholine Receptors pathway
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway
Acetylcholine Binding And Downstream Events pathway
Postsynaptic nicotinic acetylcholine receptors pathway
Highly calcium permeable nicotinic acetylcholine receptors pathway
Transmission across Chemical Synapses pathway
|
||||||||||||
KEGG |
Neuroactive ligand-receptor interaction pathway
|
||||||||||||
INOH | |||||||||||||
PID NCI | |||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Neuronal System pathway
Highly calcium permeable nicotinic acetylcholine receptors pathway
Postsynaptic nicotinic acetylcholine receptors pathway
Activation of Nicotinic Acetylcholine Receptors pathway
Presynaptic nicotinic acetylcholine receptors pathway
Transmission across Chemical Synapses pathway
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Acetylcholine Binding And Downstream Events pathway
|
||||||||||||
KEGG |
Neuroactive ligand-receptor interaction pathway
|
||||||||||||
INOH | |||||||||||||
PID NCI | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q8BMN3 | ||||||||||||
TrEMBL | Q8VI07 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 108043 | ||||||||||||
UniGene | Mm.110444 | ||||||||||||
RefSeq | NM_027454 NM_173212 | ||||||||||||
OMIM | |||||||||||||
CCDS | CCDS22216 CCDS22217 | ||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
MGI ID | MGI:106212 | ||||||||||||
MGI Symbol | Chrnb3 | ||||||||||||
EMBL | AF325350 AF467896 AK017571 AK030464 AY574268 BC058193 | ||||||||||||
GenPept | AAH58193 AAL37366 AAL75573 AAS90364 BAB30812 BAC26973 | ||||||||||||
RNA Seq Atlas | 108043 | ||||||||||||