InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHRNB3

Summary

InnateDB Gene

IDBG-20314.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRNB3

Gene Name

cholinergic receptor, nicotinic, beta 3 (neuronal)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000147432

Encoded Proteins

IDBP-20316

cholinergic receptor, nicotinic, beta 3

IDBP-594812

cholinergic receptor, nicotinic, beta 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:42697376-42737407

Strand

Forward strand

Band

p11.21

Transcripts

ENST00000289957	ENSP00000289957
ENST00000531610
ENST00000534391	ENSP00000433913

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0008144	drug binding
GO:0015267	channel activity
GO:0042166	acetylcholine binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007271	synaptic transmission, cholinergic
GO:0034220	ion transmembrane transport
GO:0051291	protein heterooligomerization
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0043005	neuron projection
GO:0045211	postsynaptic membrane