Version 5.4
Homo sapiens Gene: GCNT3
Summary
InnateDB Gene IDBG-14610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GCNT3
Gene Name glucosaminyl (N-acetyl) transferase 3, mucin type
Synonyms C2/4GnT; C24GNT; C2GNT2; C2GNTM; GNTM
Species Homo sapiens
Ensembl Gene ENSG00000140297
Encoded Proteins
IDBP-238274
glucosaminyl (N-acetyl) transferase 3, mucin type
IDBP-593103
glucosaminyl (N-acetyl) transferase 3, mucin type
IDBP-583955
glucosaminyl (N-acetyl) transferase 3, mucin type
IDBP-584493
glucosaminyl (N-acetyl) transferase 3, mucin type
IDBP-603840
glucosaminyl (N-acetyl) transferase 3, mucin type
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:59594875-59640239
Strand Forward strand
Band q22.2
Transcripts
ENST00000396065 ENSP00000379377
ENST00000558721
ENST00000560874
ENST00000560580
ENST00000560111
ENST00000559189 ENSP00000453453
ENST00000560585 ENSP00000452741
ENST00000559626 ENSP00000453928
ENST00000560210
ENST00000559200 ENSP00000453774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008375 acetylglucosaminyltransferase activity
GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
Biological Process
GO:0002426 immunoglobulin production in mucosal tissue
GO:0005975 carbohydrate metabolic process
GO:0006493 protein O-linked glycosylation
GO:0016266 O-glycan processing
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048729 tissue morphogenesis
GO:0050892 intestinal absorption
GO:0060993 kidney morphogenesis
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032226
View Gene Order
ENSBTAG00000009443
Not yet available
Pathways
NETPATH
REACTOME
REACT_115606
O-linked glycosylation of mucins pathway
REACT_22161
Post-translational protein modification pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00512
Mucin type O-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.194710 Hs.739936
RefSeq NM_004751
HUGO
OMIM
CCDS CCDS10172
HPRD 06018
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca