InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCNT3

Summary

InnateDB Protein

IDBP-583955.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCNT3

Protein Name

glucosaminyl (N-acetyl) transferase 3, mucin type

Synonyms

C2/4GnT; C24GNT; C2GNT2; C2GNTM; GNTM;

Species

Homo sapiens

Ensembl Protein

ENSP00000452741

InnateDB Gene

IDBG-14610 (GCNT3)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. {ECO:0000269PubMed:9915862}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced. {ECO:0000269PubMed:17303715, ECO:0000269PubMed:9915862}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
GO:0008375	acetylglucosaminyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006493	protein O-linked glycosylation
GO:0016266	O-glycan processing
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process