InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wasf1

Summary

InnateDB Gene

IDBG-146104.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wasf1

Gene Name

WAS protein family, member 1

Synonyms

AI195380; AI838537; Scar; WAVE; WAVE-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019831

Encoded Proteins

IDBP-146106

WASP family 1

IDBP-270733

WASP family 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112290:
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:40883475-40938570

Strand

Forward strand

Band

Transcripts

ENSMUST00000019975	ENSMUSP00000019975
ENSMUST00000105509	ENSMUSP00000101148

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0030036	actin cytoskeleton organization
GO:0072673	lamellipodium morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005856	cytoskeleton
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0045202	synapse