InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: WASF1

Summary

InnateDB Gene

IDBG-631593.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WASF1

Gene Name

Wiskott-Aldrich syndrome protein family member 1

Synonyms

WAVE1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016627

Encoded Proteins

IDBP-683134

Wiskott-Aldrich syndrome protein family member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112290:
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:40520685-40591232

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022116

ENSBTAP00000022116

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0016601	Rac protein signal transduction
GO:0030036	actin cytoskeleton organization
GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation