InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chrna6

Summary

InnateDB Gene

IDBG-146124.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrna6

Gene Name

cholinergic receptor, nicotinic, alpha polypeptide 6

Synonyms

Acra6; Nica6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031491

Encoded Proteins

IDBP-146126

cholinergic receptor, nicotinic, alpha polypeptide 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147434:
This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:27403214-27413944

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033882

ENSMUSP00000033882

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0014059	regulation of dopamine secretion
GO:0034220	ion transmembrane transport
GO:0051899	membrane depolarization

Cellular Component

GO:0005892	acetylcholine-gated channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane