InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHRNA6

Summary

InnateDB Gene

IDBG-20385.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRNA6

Gene Name

cholinergic receptor, nicotinic, alpha 6 (neuronal)

Synonyms

CHNRA6

Species

Homo sapiens

Ensembl Gene

ENSG00000147434

Encoded Proteins

IDBP-20387

cholinergic receptor, nicotinic, alpha 6

IDBP-594917

cholinergic receptor, nicotinic, alpha 6

IDBP-596799

cholinergic receptor, nicotinic, alpha 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:42752620-42796392

Strand

Reverse strand

Band

p11.21

Transcripts

ENST00000276410	ENSP00000276410
ENST00000534622	ENSP00000433871
ENST00000533810	ENSP00000434659
ENST00000530869
ENST00000529467

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding
GO:0015464	acetylcholine receptor activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0014059	regulation of dopamine secretion
GO:0034220	ion transmembrane transport
GO:0051899	membrane depolarization

Cellular Component

GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane