InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Siah2

Summary

InnateDB Gene

IDBG-146539.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Siah2

Gene Name

seven in absentia 2

Synonyms

AA415433; Sinh2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036432

Encoded Proteins

IDBP-146543

seven in absentia 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 12411493

[Homo sapiens] SIAH2 decreases TNF-alpha dependent induction of MAPK8 (JNK) activity and transcriptional activation of NF kappa B by mediating ubiquitination of TRAF2 under stress conditions.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181788:
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:58674938-58692400

Strand

Reverse strand

Band

Transcripts

ENSMUST00000070368	ENSMUSP00000067496
ENSMUST00000145032

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031624	ubiquitin conjugating enzyme binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0007275	multicellular organismal development
GO:0016567	protein ubiquitination
GO:0031396	regulation of protein ubiquitination
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044257	cellular protein catabolic process
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005769	early endosome
GO:0005829	cytosol
GO:0043005	neuron projection
GO:0043025	neuronal cell body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000181788

View Gene Order

ENSBTAG00000023445

Not yet available

Pathways

NETPATH

REACTOME

REACT_229826

Netrin-1 signaling pathway

REACT_261444

Axon guidance pathway

REACT_188576

Developmental Biology pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_22237

Netrin-1 signaling pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.2847 Mm.393631 Mm.481111

RefSeq

NM_009174

OMIM

CCDS

CCDS17368

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas