Version 5.4
Bos taurus Gene: SIAH2
Summary
InnateDB Gene IDBG-637646.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIAH2
Gene Name E3 ubiquitin-protein ligase SIAH2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000023445
Encoded Proteins
IDBP-689668
seven in absentia homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 12411493
[Homo sapiens] SIAH2 decreases TNF-alpha dependent induction of MAPK8 (JNK) activity and transcriptional activation of NF kappa B by mediating ubiquitination of TRAF2 under stress conditions.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181788:
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:118300798-118318258
Strand Forward strand
Band
Transcripts
ENSBTAT00000044404 ENSBTAP00000041904
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.
Predicted by orthology
Total 67 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organismal development
GO:0016567 protein ubiquitination
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044257 cellular protein catabolic process
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000181788
View Gene Order
ENSMUSG00000036432
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_229826
Netrin-1 signaling pathway
REACT_261444
Axon guidance pathway
REACT_188576
Developmental Biology pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MBM6
UniProt Splice Variant
Entrez Gene 785659
UniGene Bt.17299
RefSeq NM_001207054
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02002676
GenPept
RNA Seq Atlas 785659

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca