Version 5.4
Mus musculus Gene: E4f1
Summary
InnateDB Gene IDBG-146608.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E4f1
Gene Name E4F transcription factor 1
Synonyms p120E4F; phi-AP3
Species Mus musculus
Ensembl Gene ENSMUSG00000024137
Encoded Proteins
IDBP-146610
E4F transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the GLI-Kruppel zinc finger family. The encoded protein is likely to be multi-functional, with both adenovirus E1A-regulated transcription factor and ubiquitin E3 ligase activities, including roles in cell cycle regulation and the ubiquitination of p53. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:24443792-24455311
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000056032 ENSMUSP00000062344
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0035497 cAMP response element binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006260 DNA replication
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007067 mitotic nuclear division
GO:0009794 regulation of mitotic cell cycle, embryonic
GO:0010564 regulation of cell cycle process
GO:0016567 protein ubiquitination
GO:0040008 regulation of growth
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005819 spindle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167967
View Gene Order
ENSBTAG00000009961
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53regulationpathway
p53 pathway
Cross-References
SwissProt Q8CCE9
TrEMBL
UniProt Splice Variant
Entrez Gene 13560
UniGene
RefSeq NM_007893 XM_006523594 XM_006523595
OMIM
CCDS CCDS28481
HPRD
IMGT
MGI ID MGI:109530
MGI Symbol E4f1
EMBL AF126967 AK033285 AK144176 BC046459 BC057011 BC071228 X76858
GenPept AAF22563 AAH46459 AAH57011 AAH71228 BAC28222 BAE25748 CAA54188
RNA Seq Atlas 13560

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca