InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: E4f1

Summary

InnateDB Protein

IDBP-146610.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E4f1

Protein Name

E4F transcription factor 1

Synonyms

p120E4F; phi-AP3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062344

InnateDB Gene

IDBG-146608 (E4f1)

Protein Structure

UniProt Annotation

Function

May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. {ECO:0000269PubMed:10644996, ECO:0000269PubMed:15226446, ECO:0000269PubMed:17557114, ECO:0000269PubMed:8262041}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:15226446, ECO:0000269PubMed:8262041}. Cytoplasm {ECO:0000250}. Note=A small fraction is detected in the cytoplasm (By similarity). Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:8262041, ECO:0000269PubMed:9530632}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0035497	cAMP response element binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007067	mitotic nuclear division
GO:0009794	regulation of mitotic cell cycle, embryonic
GO:0010564	regulation of cell cycle process
GO:0016567	protein ubiquitination
GO:0040008	regulation of growth