Version 5.4
Mus musculus Gene: Gcm2
Summary
InnateDB Gene IDBG-146771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gcm2
Gene Name glial cells missing homolog 2 (Drosophila)
Synonyms Gcm-rs1; Gcm1; Gcm1-rs2
Species Mus musculus
Ensembl Gene ENSMUSG00000021362
Encoded Proteins
IDBP-146773
glial cells missing homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124827:
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:41101427-41109988
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000021791 ENSMUSP00000021791
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006874 cellular calcium ion homeostasis
GO:0030154 cell differentiation
GO:0030643 cellular phosphate ion homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0060017 parathyroid gland development
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124827
View Gene Order
ENSBTAG00000018787
Not yet available
Cross-References
SwissProt O09102
TrEMBL
UniProt Splice Variant
Entrez Gene 107889
UniGene Mm.1399
RefSeq NM_008104
OMIM
CCDS CCDS26472
HPRD
IMGT
MGI ID MGI:1861438
MGI Symbol Gcm2
EMBL AF081556 AF081558 BC110631 BC110632 D88611
GenPept AAC64782 AAC64784 AAI10632 AAI10633 BAA13649
RNA Seq Atlas 107889

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca