InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nrg1

Summary

InnateDB Gene

IDBG-146861.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrg1

Gene Name

neuregulin 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000062991

Encoded Proteins

IDBP-146865

neuregulin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157168:
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq, May 2009]
The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:31818028-31918203

Strand

Reverse strand

Band

Transcripts

ENSMUST00000073884

ENSMUSP00000073546

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0005102	receptor binding
GO:0005176	ErbB-2 class receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0030296	protein tyrosine kinase activator activity
GO:0043125	ErbB-3 class receptor binding

Biological Process

GO:0000165	MAPK cascade
GO:0000902	cell morphogenesis
GO:0003161	cardiac conduction system development
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399	nervous system development
GO:0007416	synapse assembly
GO:0007422	peripheral nervous system development
GO:0007507	heart development
GO:0007517	muscle organ development
GO:0007626	locomotory behavior
GO:0008283	cell proliferation
GO:0009790	embryo development
GO:0010001	glial cell differentiation
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0016477	cell migration
GO:0021781	glial cell fate commitment
GO:0030307	positive regulation of cell growth
GO:0038127	ERBB signaling pathway
GO:0042060	wound healing
GO:0042177	negative regulation of protein catabolic process
GO:0043497	regulation of protein heterodimerization activity
GO:0043624	cellular protein complex disassembly
GO:0045213	neurotransmitter receptor metabolic process
GO:0045595	regulation of cell differentiation
GO:0045785	positive regulation of cell adhesion
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046579	positive regulation of Ras protein signal transduction
GO:0048663	neuron fate commitment
GO:0051048	negative regulation of secretion
GO:0051897	positive regulation of protein kinase B signaling
GO:0055012	ventricular cardiac muscle cell differentiation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060379	cardiac muscle cell myoblast differentiation
GO:0060956	endocardial cell differentiation
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016324	apical plasma membrane
GO:0030424	axon
GO:0031594	neuromuscular junction
GO:0045202	synapse