InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Daam1

Summary

InnateDB Gene

IDBG-146871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Daam1

Gene Name

dishevelled associated activator of morphogenesis 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034574

Encoded Proteins

IDBP-146873

dishevelled associated activator of morphogenesis 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100592:
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:71831078-71992367

Strand

Forward strand

Band

Transcripts

ENSMUST00000085299

ENSMUSP00000082406

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0017048	Rho GTPase binding
GO:0042802	identical protein binding