InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Daam1

Summary

InnateDB Protein

IDBP-146873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Daam1

Protein Name

dishevelled associated activator of morphogenesis 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082406

InnateDB Gene

IDBG-146871 (Daam1)

Protein Structure

UniProt Annotation

Function

Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Perinuclear. {ECO:0000250}.

Disease Associations

Tissue Specificity

In early embryogenesis, expressed in embryonic and extraembryonic ectoderm. In later stages of gastrulation, expressed also in somites and ribs and posterior vertebrae of developing skeletal system. During organogenesis, expressed in CNS, PNS, stomach, liver and limb bud. {ECO:0000269PubMed:15464228, ECO:0000269PubMed:15533824}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0017048	Rho GTPase binding
GO:0042802	identical protein binding