InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: P2ry14

Summary

InnateDB Gene

IDBG-147059.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2ry14

Gene Name

purinergic receptor P2Y, G-protein coupled, 14

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036381

Encoded Proteins

IDBP-147061

purinergic receptor P2Y, G-protein coupled, 14

IDBP-147063

purinergic receptor P2Y, G-protein coupled, 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22778393

Deletion of P2ry14 inhibits macrophage recruitment and tissue inflammation, which mitigate diet-induced insulin resistance.

InnateDB Annotation from Orthologs

Summary

PMID 22778393

[Homo sapiens] Deletion of P2RY14 inhibits macrophage recruitment and tissue inflammation, which mitigate diet-induced insulin resistance. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174944:
The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:59114626-59130624

Strand

Reverse strand

Band

Transcripts

ENSMUST00000091112	ENSMUSP00000088642
ENSMUST00000065220	ENSMUSP00000066669

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0045028	G-protein coupled purinergic nucleotide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway
GO:0045087	innate immune response (InnateDB)