Version 5.4
| Homo sapiens Gene: P2RY14 | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-61501.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | P2RY14 | ||||||||||||||||||
| Gene Name | purinergic receptor P2Y, G-protein coupled, 14 | ||||||||||||||||||
| Synonyms | BPR105; GPR105; P2Y14 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000174944 | ||||||||||||||||||
| Encoded Proteins |
purinergic receptor P2Y, G-protein coupled, 14
purinergic receptor P2Y, G-protein coupled, 14
purinergic receptor P2Y, G-protein coupled, 14
|
||||||||||||||||||
| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
Deletion of P2RY14 inhibits macrophage recruitment and tissue inflammation, which mitigate diet-induced insulin resistance. (Demonstrated in mice)
|
||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||
| Summary |
[Mus musculus] Deletion of P2ry14 inhibits macrophage recruitment and tissue inflammation, which mitigate diet-induced insulin resistance.
|
||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
||||||||||||||||||
| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 3:151212117-151278467 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q25.1 | ||||||||||||||||||
| Transcripts |
|
||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
|
||||||||||||||||||
| Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
| Biological Process |
|
||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||
| Orthologs | |||||||||||||||||||
|
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
G alpha (i) signalling events pathway
P2Y receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Nucleotide-like (purinergic) receptors pathway
|
||||||||||||||||||
| KEGG |
Neuroactive ligand-receptor interaction pathway
|
||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | C9JAB5 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 9934 | ||||||||||||||||||
| UniGene | Hs.2465 Hs.678103 | ||||||||||||||||||
| RefSeq | NM_001081455 NM_014879 XM_005247921 XM_005247922 XM_006713832 | ||||||||||||||||||
| HUGO | HGNC:16442 | ||||||||||||||||||
| OMIM | 610116 | ||||||||||||||||||
| CCDS | CCDS3156 | ||||||||||||||||||
| HPRD | 08820 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC078816 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 9934 | ||||||||||||||||||