Version 5.4
| Mus musculus Gene: Sesn1 | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-147077.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Sesn1 | ||||||
| Gene Name | sestrin 1 | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Gene | ENSMUSG00000038332 | ||||||
| Encoded Proteins |
sestrin 1
sestrin 1
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| Protein Structure | |||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080546:
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 10:41810574-41908424 | ||||||
| Strand | Forward strand | ||||||
| Band | B2 | ||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||
| NETPATH | |||||||
| REACTOME | |||||||
| KEGG |
p53 signaling pathway pathway
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| INOH | |||||||
| PID NCI | |||||||
| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME | |||||||
| KEGG |
p53 signaling pathway pathway
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| INOH | |||||||
| PID NCI |
Direct p53 effectors
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| Cross-References | |||||||
| SwissProt | |||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | |||||||
| UniGene | Mm.139418 Mm.415868 | ||||||
| RefSeq | NM_001013370 NM_001162908 | ||||||
| OMIM | |||||||
| CCDS | CCDS23809 CCDS48550 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| MGI ID | |||||||
| MGI Symbol | |||||||
| EMBL | |||||||
| GenPept | |||||||
| RNA Seq Atlas | |||||||