Version 5.4
Mus musculus Gene: Cbx3
Summary
InnateDB Gene IDBG-147481.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cbx3
Gene Name chromobox 3
Synonyms HP1g; M32
Species Mus musculus
Ensembl Gene ENSMUSG00000029836
Encoded Proteins
IDBP-147483
chromobox homolog 3 (Drosophila HP1 gamma)
IDBP-251727
chromobox homolog 3 (Drosophila HP1 gamma)
IDBP-251729
chromobox homolog 3 (Drosophila HP1 gamma)
IDBP-251731
chromobox homolog 3 (Drosophila HP1 gamma)
IDBP-534775
chromobox homolog 3 (Drosophila HP1 gamma)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122565:
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5\' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:51470360-51483704
Strand Forward strand
Band B3
Transcripts
ENSMUST00000031862 ENSMUSP00000031862
ENSMUST00000094623 ENSMUSP00000110091
ENSMUST00000114446 ENSMUSP00000110089
ENSMUST00000114445 ENSMUSP00000110088
ENSMUST00000156463
ENSMUST00000153699
ENSMUST00000141711 ENSMUSP00000121370
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 21 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 70 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:1990226 histone methyltransferase binding
Biological Process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005719 nuclear euchromatin
GO:0005720 nuclear heterochromatin
GO:0005819 spindle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000122565
View Gene Order
ENSBTAG00000005540
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.393602 Mm.413393 Mm.423016 Mm.489750
RefSeq NM_007624 XM_619114 XM_893413
OMIM
CCDS CCDS20135
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca