InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Abca1

Summary

InnateDB Gene

IDBG-147642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abca1

Gene Name

ATP-binding cassette, sub-family A (ABC1), member 1

Synonyms

ABC-1; Abc1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015243

Encoded Proteins

IDBP-147644

ATP-binding cassette, sub-family A (ABC1), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22955730

Abca1 deletion in the myeloid lineage enhances host immune response and clearance of Listeria monocytogenes.

InnateDB Annotation from Orthologs

Summary

PMID 20472936

[Homo sapiens] ABCA1 promotes the efflux of bacterial lipopolysaccharide (LPS) from macrophages and accelerates recovery from LPS-induced tolerance.

PMID 20650929

[Homo sapiens] ABCA1 in macrophages dampens inflammation by reducing MYD88-dependent TLR trafficking to lipid rafts, thus selectively reducing free cholesterol content in lipid rafts.

PMID 22955730

[Homo sapiens] ABCA1 deletion in the myeloid lineage enhances host immune response and clearance of Listeria monocytogenes. (Demonstrated in mice)

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier\'s disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:53030787-53159895

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030010	ENSMUSP00000030010
ENSMUST00000149127

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005548	phospholipid transporter activity
GO:0008509	anion transmembrane transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0017127	cholesterol transporter activity
GO:0019905	syntaxin binding
GO:0031267	small GTPase binding
GO:0034185	apolipoprotein binding
GO:0034186	apolipoprotein A-I binding
GO:0034188	apolipoprotein A-I receptor activity
GO:0051117	ATPase binding

Biological Process

GO:0002790	peptide secretion
GO:0006200	ATP catabolic process
GO:0006497	protein lipidation
GO:0006911	phagocytosis, engulfment
GO:0007040	lysosome organization
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007584	response to nutrient
GO:0008203	cholesterol metabolic process
GO:0010875	positive regulation of cholesterol efflux
GO:0015914	phospholipid transport
GO:0016197	endosomal transport
GO:0030301	cholesterol transport
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032367	intracellular cholesterol transport
GO:0032489	regulation of Cdc42 protein signal transduction
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034380	high-density lipoprotein particle assembly
GO:0034616	response to laminar fluid shear stress
GO:0038027	apolipoprotein A-I-mediated signaling pathway
GO:0042157	lipoprotein metabolic process
GO:0042158	lipoprotein biosynthetic process
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0043691	reverse cholesterol transport
GO:0045087	innate immune response (InnateDB)
GO:0045332	phospholipid translocation
GO:0050702	interleukin-1 beta secretion
GO:0055091	phospholipid homeostasis
GO:0055098	response to low-density lipoprotein particle stimulus
GO:0060155	platelet dense granule organization
GO:0071222	cellular response to lipopolysaccharide
GO:0071300	cellular response to retinoic acid
GO:0071397	cellular response to cholesterol

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0030139	endocytic vesicle
GO:0034364	high-density lipoprotein particle
GO:0043231	intracellular membrane-bounded organelle
GO:0045121	membrane raft
GO:0045335	phagocytic vesicle
GO:0048471	perinuclear region of cytoplasm