Version 5.4
Mus musculus Gene: Chat
Summary
InnateDB Gene IDBG-147704.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chat
Gene Name choline acetyltransferase
Synonyms B230380D24Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000021919
Encoded Proteins
IDBP-147706
choline acetyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23297238
Chat is expressed by lymphocytes to regulate local recruitment of neutrophils.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070748:
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer\'s disease. Polymorphisms in this gene have been associated with Alzheimer\'s disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:32408203-32465909
Strand Reverse strand
Band B
Transcripts
ENSMUST00000070125 ENSMUSP00000070865
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004102 choline O-acetyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0007268 synaptic transmission
GO:0007274 neuromuscular synaptic transmission
GO:0007517 muscle organ development
GO:0007529 establishment of synaptic specificity at neuromuscular junction
GO:0007622 rhythmic behavior
GO:0007628 adult walking behavior
GO:0008152 metabolic process
GO:0016358 dendrite development
GO:0030182 neuron differentiation
GO:0043179 rhythmic excitation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005739 mitochondrion
GO:0030424 axon
GO:0043005 neuron projection
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000070748
View Gene Order
ENSBTAG00000016814
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121238
Synthesis of PC pathway
REACT_15309
Acetylcholine Neurotransmitter Release Cycle pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_13685
Neuronal System pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q8BQV2
UniProt Splice Variant
Entrez Gene 12647
UniGene Mm.442817
RefSeq NM_009891
OMIM
CCDS CCDS26920
HPRD
IMGT
MGI ID MGI:88392
MGI Symbol Chat
EMBL AC167565 AK046406 BC119322 BC120589
GenPept AAI19323 AAI20590 BAC32710
RNA Seq Atlas 12647

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca