InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CHAT

Summary

InnateDB Gene

IDBG-631789.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHAT

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016814

Encoded Proteins

IDBP-683398

choline O-acetyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23297238

[Mus musculus] Chat is expressed by lymphocytes to regulate local recruitment of neutrophils.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070748:
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer\'s disease. Polymorphisms in this gene have been associated with Alzheimer\'s disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:44143245-44187239

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022369

ENSBTAP00000022369

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004102	choline O-acetyltransferase activity
GO:0016740	transferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0007268	synaptic transmission
GO:0007274	neuromuscular synaptic transmission
GO:0007517	muscle organ development
GO:0007529	establishment of synaptic specificity at neuromuscular junction
GO:0007622	rhythmic behavior
GO:0007628	adult walking behavior
GO:0008152	metabolic process
GO:0016358	dendrite development
GO:0030182	neuron differentiation
GO:0043179	rhythmic excitation